Anharmonic Torsional Stiffness of DNA Revealed under Small External Torques
نویسندگان
چکیده
منابع مشابه
Anharmonic torsional stiffness of DNA revealed under small external torques.
DNA supercoiling plays an important role in a variety of cellular processes. The torsional stress related to supercoiling may also be involved in gene regulation through the local structure and dynamics of the double helix. To check this possibility, steady torsional stress was applied in the course of all-atom molecular dynamics simulations of two DNA fragments with different base pair sequenc...
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Negatively twisted DNA is essential to many biological functions. Due to torsional stress, duplex DNA can have local, sequence-dependent structural defects. In this work, a thermodynamic model of DNA was built to qualitatively predict the local sequence-dependent mechanical instabilities under torsional stress. The results were compared to both simulation of a coarse-grained model and experimen...
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DNA and other biopolymers differ from classical polymers because of their torsional stiffness. This property changes the statistical character of their conformations under tension from a classical random walk to a problem we call the "torsional directed walk." Motivated by a recent experiment on single lambda-DNA molecules [Strick, T. R., Allemand, J.-F., Bensimon, D., Bensimon, A. & Croquette,...
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When the out-of-plane stiffness of a beam is remarkably lower than the in-plane stiffness, the lateral-torsional buckling occurs. In this study, the behavior of mono-symmetric I-beams with discrete torsional and lateral bracings under the concentrated moment is investigated using the finite element analyses. Then, based on the numerical analyses, equation for the stiffness requirement is propos...
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Regions of the genome are often held under torsional constraint. Nevertheless, the influence of such constraint on DNA-protein interactions during genome metabolism is still poorly understood. Here using a combined optical tweezers and fluorescence microscope, we quantify and explain how torsional constraint influences the structural stability of DNA under applied tension. We provide direct evi...
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ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2010
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.105.018102